GIRA

2025

Changes in T Lymphocytes and Cytokines After Anti-TNF Treatment in Pediatric Inflammatory Bowel Disease: Association with Response to Pharmacologic Therapy

Zapata-Cobo P, Salvador-Martín S, Gil-Manso S, Velasco Rodríguez-Belvís M, Palomino LM, Moreno-Álvarez A, Pérez-Moneo B, García-Romero R, Fobelo MJ, García-Tirado D, Sánchez C, Pujol-Muncunill G, Segarra O, Montraveta M, Magallares L, Correa-Rocha R, Sanjurjo-Sáez M, Pion M*, and López-Fernández LA*. (2025) doi: 10.1172/jci.insight.177899. Free PMC article

2024

Progesterone promotes Cxcl2-dependent vaginal neutrophil killing by activating cervical resident macrophage-neutrophil crosstalk

Gomez-Oro C, Latorre MC, Arribas-Poza P, Ibanez-Escribano A, Baca-Cornejo K, Gallego-Valle J, Liopez-Escobar N, Mondejar-Palencia, Pion M, Lopez-Fernandez LA, Mercader-Cidoncha, Perez-Milam F, Relloso M. (2024) Sept. doi: 10.1172/jci.insight.177899. Free PMC article

High specificity of engineered T cells with third generation CAR (CD28-4-1BB-CD3-ζ) based on biotin-bound monomeric streptavidin for potential tumor immunotherapy

Gallego-Valle J, Pérez-Fernández VA, Rosales-Magallares J, Gil-Manso S, Castella M, González-Navarro EA, Correa-Rocha R, Juan M, Pion M. (2024) Sept. doi: 10.3389/fimmu.2024.1448752. Free PMC article

Design and validation of novel flow cytometry panels to analyze a comprehensive range of peripheral immune cells in mice

Barco-Tejada A, López-Esteban R, Mulero F, Pion M, Correa-Rocha R, Desco M, Cusso L. Front Immunol.  (2024) Aug 13;15:1432816. Free PMC article

Neutralizing antibody levels detected early after mRNA-based vaccination do not predict by themselves subsequent breakthrough infections of SARS-CoV-2

Alonso R, Gil-Manso S, Catalan P, sanchez-Arcilla I, Marzola M, Correa-Rocha R, Muñoz P,  Pion M. Front Immunol.  (2024) Feb 9;15:1341313. Free PMC article

Digital PCR Improves Sensitivity and Quantification in Monitoring CAR-T Cells in B Cell Lymphoma Patients.

de la Iglesia-San Sebastian I, Carbonell D, Bastos-Oreiro M, Perez-Coral A, Bailen R, Chicano M, Muñiz P, Monsalvo S, Escudero-Fernandez A, Oarbeascoa G, Fernandez-Caldas P, Gomez-Centurion I, Pion M, Gayoso J, Anguita J, Kwon M, Diez-Martin JL, Buño I, Martinez-Laperche C. Transplant Cell Ther (2024) Jan 5:S2666-6367(23)02411-9. Free PMC article

2023

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant.

Bernaldo-de-Quirós E, Camino M, Martínez-Bonet M, Gil-Jaurena JM, Gil N, Hernández-Flórez D, Fernández-Santos ME, Butragueño L, Dijke E, Levings MK, West LJ, Pion M, Correa-Rocha R. J Exp Med (2023) 220 (12): e20231045. Free PMC article.

Multidimensional analysis of immune cells from COVID-19 patients identified cell subsets associated with the severity at hospital admission.

Gil-Manso S, Herrero-Quevedo D, Carbonell D, Martínez-Bonet M, Bernaldo-de-Quirós E, Kennedy-Batalla R, Gallego-Valle J, López-Esteban R, Blázquez-López E, Miguens-Blanco I, Correa-Rocha R, Gomez-Verdejo V, Pion M.
PLoS Pathog. 2023 Jun13;19(6):e1011432. PMID: 37311004. Free PMC article.

2022

IgG anti-RBD levels during 8-month follow-up post-vaccination with BNT162b2 and mRNA-1273 vaccines in healthcare workers: A one-center study.

Gil-Manso S, Alonso R, Catalán P, Sánchez-Arcilla I, Marzola M, Correa-Rocha R, Pion M, Muñoz P. Front Cell Infect Microbiol. 2022 Nov 30;12:1035155. doi: 10.3389/fcimb.2022.1035155. eCollection 2022.PMID: 36530428 Free PMC article.

Cellular and Humoral Responses Follow-up for 8 Months after Vaccination with mRNA-Based Anti-SARS-CoV-2 Vaccines.

Gil-Manso S, Carbonell D, Pérez-Fernández VA, López-Esteban R, Alonso R, Muñoz P, Ochando J, Sánchez-Arcilla I, Bellón JM, Correa-Rocha R, Pion M. Biomedicines. 2022 Jul 12;10(7):1676. doi: 10.3390/biomedicines10071676.PMID: 35884980 Free PMC article.

A Novel GMP Protocol to Produce High-Quality Treg Cells From the Pediatric Thymic Tissue to Be Employed as Cellular Therapy.

Bernaldo-de-Quirós E, Cózar B, López-Esteban R, Clemente M, Gil-Jaurena JM, Pardo C, Pita A, Pérez-Caballero R, Camino M, Gil N, Fernández-Santos ME, Suarez S, Pion M, Martínez-Bonet M, Correa-Rocha R. Front Immunol. 2022 May 16;13:893576. doi: 10.3389/fimmu.2022.893576. eCollection 2022.PMID: 35651624 Free PMC article.

A New Generation of Cell Therapies Employing Regulatory T Cells (Treg) to Induce Immune Tolerance in Pediatric Transplantation.

Bernaldo-de-Quirós E, Pion M, Martínez-Bonet M, Correa-Rocha R. Front Pediatr. 2022 May 11;10:862807. doi: 10.3389/fped.2022.862807. eCollection 2022.PMID: 35633970 Free PMC article. Review.

Comprehensive Flow Cytometry Profiling of the Immune System in COVID-19 Convalescent Individuals.

Gil-Manso S, Miguens Blanco I, López-Esteban R, Carbonell D, López-Fernández LA, West L, Correa-Rocha R, Pion M. Front Immunol. 2022 Jan 6;12:793142. doi: 10.3389/fimmu.2021.793142. eCollection 2021.PMID: 35069575 Free PMC article.

Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel.

Martín-Rojas RM, Gómez-Centurión I, Bailén R, Bastos M, Diaz-Crespo F, Carbonell D, Correa-Rocha R, Pion M, Muñoz C, Sancho M, Gómez Fernández I, Oarbeascoa G, Pérez-Corral A, Martínez-Laperche C, Anguita J, Buño I, Menárguez J, Díez-Martín JL, Kwon M. Clin Case Rep. 2022 Jan 7;10(1):e05209. doi: 10.1002/ccr3.5209. eCollection 2022 Jan.PMID: 35028140 Free PMC article.

ABO blood group is involved in the quality of the specific immune response anti-SARS-CoV-2.

Gil-Manso S, Miguens Blanco I, Motyka B, Halpin A, López-Esteban R, Pérez-Fernández VA, Carbonell D, López-Fernández LA, West L, Correa-Rocha R, Pion M. Virulence. 2022 Dec;13(1):30-45. doi: 10.1080/21505594.2021.2019959.PMID: 34967260 Free PMC article.

2021

Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several Days.

Gil-Manso S, Carbonell D, López-Fernández L, Miguens I, Alonso R, Buño I, Muñoz P, Ochando J, Pion M, Correa-Rocha R. Front Immunol. 2021 Oct 4;12:726960. doi: 10.3389/fimmu.2021.726960. eCollection 2021.PMID: 34671348 Free PMC article.

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals.

Lozano-Ojalvo D, Camara C, Lopez-Granados E, Nozal P, Del Pino-Molina L, Bravo-Gallego LY, Paz-Artal E, Pion M, Correa-Rocha R, Ortiz A, Lopez-Hoyos M, Iribarren ME, Portoles J, Rojo-Portoles MP, Ojeda G, Cervera I, Gonzalez-Perez M, Bodega-Mayor I, Montes-Casado M, Portoles P, Perez-Olmeda M, Oteo J, Sanchez-Tarjuelo R, Pothula V, Schwarz M, Brahmachary M, Tan AT, Le Bert N, Berin C, Bertoletti A, Guccione E, Ochando J. Cell Rep. 2021 Aug 24;36(8):109570. doi: 10.1016/j.celrep.2021.109570. Epub 2021 Aug 4.PMID: 34390647 Free PMC article.

The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Bernaldo-de-Quirós E, López-Abente J, Camino M, Gil N, Panadero E, López-Esteban R, Martínez-Bonet M, Pion M, Correa-Rocha R. Transplant Direct. 2021 Apr 23;7(5):e693. doi: 10.1097/TXD.0000000000001152. eCollection 2021 May.PMID: 33928185 Free PMC article.

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Gallego-Valle J, Gil-Manso S, Pita A, Bernaldo-de-Quirós E, López-Esteban R, Martínez-Bonet M, Pérez-Fernández VA, Pérez-Caballero R, Pardo C, Gil-Jaurena JM, Correa-Rocha R, Pion M. Biomedicines. 2021 Apr 23;9(5):461. doi: 10.3390/biomedicines9050461.PMID: 33922629 Free PMC article.

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.

López-Abente J, Martínez-Bonet M, Bernaldo-de-Quirós E, Camino M, Gil N, Panadero E, Gil-Jaurena JM, Clemente M, Urschel S, West L, Pion M, Correa-Rocha R. Sci Rep. 2021 Jan 12;11(1):827. doi: 10.1038/s41598-020-80567-9.PMID: 33436905 Free PMC article.

2019

Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome.

Hernández-Martín A, Kennedy-Batalla R, Cañedo E, Bernaldo-de-Quirós E, Carazo-Gallego B, Vera A, Torrelo A, Noguera-Morel L, González-Sarmiento R, Bolling M, Martínez-Bonet M, Pion M, Correa-Rocha R. N Engl J Med. 2019 Nov 28;381(22):2176-2178. doi: 10.1056/NEJMc1908531.PMID: 31774967 No abstract available.

Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients.

Gutiérrez C, Lopez-Abente J, Pérez-Fernández V, Prieto-Sánchez A, Correa-Rocha R, Moreno-Guillen S, Muñoz-Fernández MÁ, Pion M. PLoS One. 2019 Mar 27;14(3):e0213744. doi: 10.1371/journal.pone.0213744. eCollection 2019.PMID: 30917149 Free PMC article.

Immune dysregulation and Th2 polarization are associated with atopic dermatitis in heart-transplant children: A delicate balance between risk of rejection or atopic symptoms.

López-Abente J, Bernaldo-de-Quirós E, Camino M, Gil N, Panadero E, Campos-Domínguez M, Seoane-Reula E, Gil-Jaurena JM, Pion M, Correa-Rocha R. Am J Transplant. 2019 May;19(5):1536-1544. doi: 10.1111/ajt.15245. Epub 2019 Jan 25.PMID: 30614192 Free article.

2018

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.

Correa-Rocha R, Lopez-Abente J, Gutierrez C, Pérez-Fernández VA, Prieto-Sánchez A, Moreno-Guillen S, Muñoz-Fernández MÁ, Pion M. PLoS One. 2018 Aug 30;13(8):e0203419. doi: 10.1371/journal.pone.0203419. eCollection 2018.PMID: 30161254 Free PMC article.

Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides.

Gallego-Valle J, Pérez-Fernández VA, Correa-Rocha R, Pion M. Int J Mol Sci. 2018 Jun 12;19(6):1737. doi: 10.3390/ijms19061737.PMID: 29895745 Free PMC article.

Corrigendum: Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.

López-Abente J, Correa-Rocha R, Pion M. Front Immunol. 2018 Apr 19;9:792. doi: 10.3389/fimmu.2018.00792. eCollection 2018.PMID: 29713329 Free PMC article.

2017

Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro.

Lopez-Abente J, Prieto-Sanchez A, Muñoz-Fernandez MÁ, Correa-Rocha R, Pion M. Cell Mol Immunol. 2018 Oct;15(10):917-933. doi: 10.1038/cmi.2017.48. Epub 2017 Jul 17.PMID: 28713164 Free PMC article.